HORDB

ID: hor005775
Uniprot ID: P07198
Protein name: Xenopsin precursor fragment
Gene name: NA
Organism: Xenopus laevis (African clawed frog)
Family: Gastrin/cholecystokinin family, Magainin subfamily
Source: animal
Expression: XPF is synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa, it is stored as active, processed peptides in large granules within the granular gland secretions of the skin.
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: NA
GO BP: GO:0042742 defense response to bacterium; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Sequence: GWASKIGQTLGKIAKVGLKELIQPK
Length: 25(39-63)
Propeptide: MYKGIFLCVLLAVICANSLATPSSDADEDNDEVERYVRGWASKIGQTLGKIAKVGLKELIQPKREAMLRSAEAQGKRPWIL
Signal peptide: MYKGIFLCVLLAVICANSLA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Xenopsin is a neurotensin-like octapeptide.; XPF has antimicrobial activity.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005775_AF2.pdb

hor005775_ESM.pdb

Mass:	309252	Formula:	C123H211N33O32
Absent amino acids:	CDFHMNRY	Common amino acids:	K
pI:	10.98	Basic residues:	5
Polar residues:	6	Hydrophobic residues:	10
Hydrophobicity:	-11.6	Boman Index:	-834
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	113.2
Instability Index:	-414.8	Extinction Coefficient cystines:	5500
Absorbance 280nm:	229.17

PubMed ID: 6582494
Title: Xenopsin: the neurotensin-like octapeptide from Xenopus skin at the carboxyl terminus of its precursor.
PubMed ID: 2830279
Title: Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences.
PubMed ID: 2465151
Title: The genes for the frog skin pept
PubMed ID: 1717472
Title:
PubMed ID: 4783175
Title: